Deterioration | Science Based Nutrition

March 3, 2010

Exercise counters negative effects of weight regain, researchers find

Filed under: Main Content — Tags: Counters, Deterioration, Disease Risk, Exercise, Health, Improvements, Losing Weight, Weight Losing — ScienceDaily: Nutrition News @ 12:00 am

Losing weight can improve health and reduce disease risk, but many people have difficulty keeping the weight off. Now, researchers have found that exercising during weight regain can maintain improvements in metabolic health and disease risk. In the study, individuals who didn't exercise during weight regain experienced significant deterioration in metabolic health, while those who exercised maintained improvements in almost all areas.

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February 2, 2010

Magnesium supplement helps boost brainpower

Filed under: Main Content — Tags: Brain Learning, Cognitive Abilities, Cognitive Function, Deterioration, Impair, Inadequate Levels, Learning And Memory, Magnesium Supplement, Rats, Speculation, Study Suggests That, Valid Strategy — ScienceDaily: Dietary Supplement News @ 3:00 am

New research finds that an increase in brain magnesium improves learning and memory in young and old rats. The study suggests that increasing magnesium intake may be a valid strategy to enhance cognitive abilities and supports speculation that inadequate levels of magnesium impair cognitive function, leading to faster deterioration of memory in aging humans.

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August 26, 2009

Half Of Somalia Needs Emergency Aid, Significant Deterioration In Food Security, Report Says

Filed under: Aid / Disasters — Tags: 18 Years, Bloomberg Reports, Civil War, Country Population, Deterioration, Emergency Aid, Emergency Food, Faces, Food Analysis, Food Nutrition, Food Security, Humanitarian Crisis, Nutrition Analysis, Security Report, Somalia — Nutrition / Diet News From Medical News Today @ 4:00 am

Somalia faces its "worst humanitarian crisis since civil war began in the country 18 years ago, with half of the country's population in need of emergency aid," the Food Security and Nutrition Analysis Unit (FSNAU), a U.N. agency, said in a report (pdf) released Monday, Bloomberg reports (McLure, 8/25).

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February 5, 2012

Reduced caloric intake during endotoxemia reduces arginine availability and metabolism [Nutritional support]

Filed under: Main Content — Tags: Adaptive Response, Amino Acid, Caloric Intake, Citrulline, Deterioration, Endotoxemia, Experimental Model, Hypothesis, Infusion, L Arginine, Lactate Pyruvate, Metabolic Changes, Phenylalanine, Protein Metabolism, Protein Synthesis, Randomized Trial, Regimen, Sepsis, Support Background, Tyrosine — Poeze, M., Bruins, M. J, Luiking, Y. C, Deutz, N. E @ 7:49 am

Background: Inadequate caloric intake increases the risk of sepsis-induced complications. Metabolic changes during sepsis indicate that the availability of the amino acid l-arginine decreases. Availability of arginine may further decrease during reduced caloric intake, which thereby limits the adaptive response of arginine–nitric oxide metabolism during sepsis.Objective: We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability.

Design: In a randomized trial, a 7-d reduced caloric intake feed regimen (RE; n = 9) was compared with a normal control feed regimen (CE; n = 9), before 24 h of endotoxemia, as a model for sepsis. Whole-body arginine–nitric oxide metabolism and protein metabolism were measured by using a stable-isotope infusion of [¹⁵N₂]arginine, [¹³C-²H₂]citrulline, [²H₅]phenylalanine, and [²H₂]tyrosine. Plasma pyruvate and lactate concentrations were determined by fully automated HPLC.

Results: Pre-endotoxin arginine appearance was significantly lower in the RE group than in the CE group (P = 0.002). During endotoxemia, arginine appearance increased in the CE animals but not in the RE animals (P = 0.04). In addition, nitric oxide production was significantly lower in the RE animals (P < 0.0001). Protein synthesis was significantly lower at the start of endotoxin infusion (P < 0.05) and remained lower during endotoxemia in the RE group than in the CE group (P < 0.001). The lactate:pyruvate ratio was not higher in the RE group than in the CE group before endotoxemia but increased significantly during endotoxemia in the RE group (P = 0.04).

Conclusion: A well-nourished condition before prolonged endotoxemia results in a better ability to adapt to endotoxin-induced metabolic deterioration of arginine–nitric oxide metabolism than does reduced caloric intake before endotoxemia.

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