Polyunsaturated Fatty Acids | Science Based Nutrition

February 2, 2010

Fish oil may reduce the risk of psychotic disorders in high-risk individuals

Filed under: Main Content — Tags: Fish Oil Capsules, High Risk, Omega 3 Polyunsaturated Fatty Acids, Polyunsaturated Fatty Acids, Psychotic Disorders, Risk Individuals — ScienceDaily: Dietary Supplement News @ 9:00 am

Individuals at extremely high risk of developing psychosis appear less likely to develop psychotic disorders following a 12-week course of fish oil capsules containing long-chain omega-3 polyunsaturated fatty acids, according to a report.

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November 30, 2009

Polyphenols and polyunsaturated fatty acids boost the birth of new neurons, study finds

Filed under: Main Content — Tags: Areas Of The Brain, Brain Stem, Cell Proliferation, Control Diet, Diet Boost, Differentiation, Hippocampus, Mice, Neurogenesis, New Spain, Olfactory Bulb, Polyunsaturated Fatty Acids, Stem Cells, Two Areas, Types Of Neuron — ScienceDaily: Nutrition News @ 3:00 am

Researchers in Spain have confirmed that a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -- neurogenesis -- and strengthens their differentiation in different types of neuron cells. The research revealed that mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus.

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November 26, 2009

The Birth Of New Neurons Boosted By Polyphenols And Polyunsaturated Fatty Acids

Filed under: Alzheimer's / Dementia — Tags: Barcelona, Brain, Diet Boost, Differentiation, Neurogenesis, Neurons, Polyunsaturated Fatty Acids, Stem Cells, Types Of Neuron, Uab Researchers — Nutrition / Diet News From Medical News Today @ 1:00 am

Universitat AutÃ²noma de Barcelona (UAB) researchers have confirmed that a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells...

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November 23, 2009

Metabolomics uncovers key indicators of nonalcoholic fatty liver disease

Filed under: Main Content — Tags: Fatty Liver Disease, Metabolomics, Nafl, Nonalcoholic Steatohepatitis, Oxidation, Plasma, Polyunsaturated Fatty Acids, Steatohepatitis Nash — ScienceDaily: Dietary Supplement News @ 10:00 pm

A recent metabolomics study found that impaired peroxisomal oxidation of polyunsaturated fatty acids is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). The study also found significantly higher plasma monounsaturated fatty acids in the blood of patients with NAFL and NASH.

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August 20, 2009

Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis [Lipids]

Filed under: Main Content — Tags: 3 Fatty Acids, Biological Mechanisms, Cholesterol, Conclusions, Control Subjects, Cystic Fibrosis, Fatty Acid Metabolism, Fatty Acid Profile, Interplay, Lipids, Lt, Mass Spectrometry, Ml, Molecules, Oleic Acid, Oxidation Products, Oxidative Stress, Polyunsaturated Fatty Acids, Prototype, Saturated Fatty Acids — Iuliano, L., Monticolo, R., Straface, G., Zullo, S., Galli, F., Boaz, M., Quattrucci, S. @ 2:00 pm

Background: Disarrangement in fatty acids and oxidative stress are features of cystic fibrosis. Cholesterol is very sensitive to oxidative stress.

Objectives: The objectives were to examine whether cholesterol oxidation products are altered in cystic fibrosis and whether they are associated with fatty acids and with characteristics of the disease state.

Design: 7-Ketocholesterol and 7β-hydroxycholesterol (prototype molecules of free radical–mediated cholesterol oxidation) and the fatty acid profile were assessed by mass spectrometry in patients and in sex- and age-matched control subjects.

Results: In a comparison with control subjects, mean (±SD) cholesterol oxidation was higher (7-ketocholesterol: 11.31 ± 5.1 compared with 8.33 ± 5.5 ng/mL, P = 0.03; 7β-hydroxycholesterol: 14.5 ± 6.8 compared with 9.7 ± 4.1 ng/mL, P = 0.004), total saturated fatty acids were higher (31.90 ± 1.93% compared with 30.31 ± 0.98%, P < 0.001), monounsaturated fatty acids were higher (29.14 ± 3.85% compared with 25.88 ± 2.94%, P = 0.004), -6 (n–6) polyunsaturated fatty acids were lower (34.84 ± 4.77 compared with 39.68 ± 2.98%, P < 0.0001), and -3 (n–3) polyunsaturated fatty acids were comparable in patients with cystic fibrosis. Oxysterols were inversely associated with 24:0 and 18:2 -6 fatty acids but did not correlate with the increased oleic acid or with any of the -3 fatty acids.

Conclusions: Cystic fibrosis is characterized by relevant cholesterol oxidation that is associated with an abnormal fatty acid profile. The interplay between oxysterols and fatty acids potentially provides insight into the biological mechanisms that underlie this complex disease.

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